• Selective pharmacological inhibition of tonic currents indic

  2021-10-16

  

  Selective pharmacological inhibition of tonic currents indicated that the effects of gp120 are predominantly mediated by α5-containing GABAARs. The other dominant subtype that contributes to tonic current in the hippocampus, the δ-containing GABAAR, was unaffected by gp120 treatment. Additionally, i

• To investigate if such an

  2021-10-16

  

  To investigate if such an effect is observed in native GlyT1, we introduced S605D and S605A mutations into GlyT1 and transfected these DNA constructs into N2a cells. For an internal control of calpain cleavage, we also introduced the first 100 amino-acids of the rat GlyT2N terminus upstream of the m

• Long non coding RNAs lncRNAs are mRNA like transcripts of

  2021-10-16

  

  Long non-coding RNAs (lncRNAs) are mRNA-like transcripts of greater than 200 nucleotides (nt), with little or no protein-coding potential [13,14]. LncRNAs have been suggested to participate in transcription and post-transcription regulation as scaffolds, guides, decoys or repressors, activators, and

• br Acknowledgements This work was supported by the National

  2021-10-16

  

  Acknowledgements This work was supported by the National Institutes of Health [grant number GM024417]. Introduction In mammals, glucose is the major energy substrate supporting conceptus development after AG-221 formation [1,2]. While the equine morula uses similar amounts of pyruvate and gl

• br Results br Discussion Using a novel

  2021-10-16

  

  Results Discussion Using a novel viral vector for norepinephrine-targeted gene deletion, we have shown that glucocorticoid receptor Atazanavir from locus coeruleus norepinephrine neurons reduces social interaction specifically in female mice. This effect is not attributable to changes in novel

• daunorubicin br Methods br Results Top

  2021-10-16

  

  Methods Results Top panels of the Fig. 1 show the conventional representation of the predicted values of TL,CO according to ERS’93 and GLI′17 as a function of age and keeping the height constant (160 cm, panel A and 190 cm, panel B). This figure shows that the GLI-‘17 predicted values of TL,CO

• br Conclusions In this study

  2021-10-15

  

  Conclusions In this study, we discovered that the G-quadruplex (Q1) formed by S1 sequence in the upstream region of the transcription start site of c-Myb gene functioned as a positive transcriptional regulator, which was different from the most cases that G-rich sequences functioned to impair the

• Acknowledgments This work was supported

  2021-10-15

  

  Acknowledgments This work was supported by the Natural Science Foundation of China (Nos. 21602254, 81603194), the Natural Science Foundation of Jiangsu province, China (BK20160767) and National Found for Fostering Talents of Basic Science (NFFTBS, J1310032). Introduction Glucocorticoids (GC) pl

• Free fatty acids FFAs which are obtained

  2021-10-15

  

  Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty rilpivirine receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Short

• Adipocytes play diverse roles in

  2021-10-15

  

  Adipocytes play diverse roles in energy homeostasis by controlling energy consumption [8] and function as a source of proteins and cytokines, which mediate numerous physiological functions [9]. Excessive accumulation of adipocytes, as well as an increase in either their size or number, causes obesit

• This study has some limitations The

  2021-10-15

  

  This study has some limitations. The RDS technique was not effective for the population of MSM from Natal, as it has not reached the sample size initially calculated. Few seeds had enough waves to disperse the sample and make it closer to a probabilistic sample, even with all efforts from the resear

• Despite these data implicating Kdm b

  2021-10-15

  

  Despite these data implicating Kdm6b as a positive regulator of neuronal differentiation, and surprisingly, given the evidence that germline knockouts die perinatally due to an inability to breathe, the brains of Kdm6b knockout mice are remarkably normal in gross morphology [26,]. Interestingly, Kdm

• po1 Multiple subsets of Breg cells in mice

  2021-10-15

  

  Multiple subsets of Breg cells in mice have been identified that could suppress the T cell-mediated response. However, a lack of consensus surface markers for Breg cells made it difficult to judge whether Breg cells are a special B cell subset or whether all po1 have an immuno-regulatory function u

• It has been known for some time

  2021-10-15

  

  It has been known for some time that an oral salt load given to mammals induces a much greater natriuresis than the intravenous administration of an equivalent amount of saline (Carey et al., 1976, Singer et al., 1998). In addition, oral administration of salt to rats has been reported to augmented

• Although it has been observed in numerous studies and by

  2021-10-15

  

  Although it has been observed in numerous studies and by many investigators that intraplatelet cGMP elevation results in platelet inhibition, there are a few papers which proposed a platelet stimulatory role for cGMP when elevated in response to NO donors or PDE5 inhibitors in mouse and human platel

14912 records 548/995 page Previous Next First page 上5页 546547548549550 下5页 Last page