• The Hippo pathway is a growth control signaling cascade that

  2021-11-15

  

  The Hippo pathway is a growth control signaling cascade that has been demonstrated to play an important role in regulating cell proliferation and differentiation [5,6]. The core signaling pathway consists of a group of kinases which negatively regulate the expression of transcriptional co-activators

• siRNA construction and transfection For small interfering

  2021-11-12

  

  siRNA construction and transfection. For small interfering RNA (siRNA) experiments, we used Stealth™ select RNAi oligonucleotides targeted against GPR120 (Gibco/Invitrogen). The target sequence of siGPR120 used were; sense 5′-AAGUGGGUGCGAUUGACUUGGUCCA-3′ and antisense 5′-UGGACCAAGUCAAUCGCACCCACUU-3′

• IBs had a clear vesicular ultrastructure

  2021-11-12

  

  IBs had a clear vesicular ultrastructure, suggesting that a large part of the iron-containing mitochondrial remnants might be cleared via normal autophagy processes during final reticulocyte maturation [21]. IB formation was followed by characteristic changes in RBC morphology, with irregularly shap

• Hippocampal lesioned mice were less able to withhold

  2021-11-12

  

  Hippocampal-lesioned mice were less able to withhold responding during a DRL-10 requirement (i.e. when the animals had to wait 10s between lever presses), and were thus less efficient than sham operated controls. In contrast, GluR-A−/− mice did not differ from wild-type mice when the DRL requirement

• br Acknowledgments This work was funded by NIH

  2021-11-12

  

  Acknowledgments This work was funded by NIH Grant 2R01 MH066958 (JGT) and NSF CAREER award IOS- 1053716 (NV). We thank Dr. Greti Aguilera for the generous gift of the GRE-Luciferase construct and Dr. Louis Muglia for the generous gift of the GR-GFP construct. Introduction Prostate cancer (PCa

• Here we examined whether complete ablation of GIP production

  2021-11-12

  

  Here, we examined whether complete ablation of GIP production could reduce weight gain in the absence of the adipocyte hormone leptin, a condition that results in extreme hyperphagia, obesity, hyperinsulinemia, and insulin resistance, in both mice [24] and humans [25]. We found that Lepob/ob mice be

• GLP and glucose dependent insulinotropic peptide GIP are

  2021-11-12

  

  GLP-1 and glucose-dependent insulinotropic peptide (GIP) are gut hormones secreted from intestinal L EKI-785 australia and K cells, respectively. Together, these hormones account for the vast majority of the incretin effect, the enhanced postprandial insulin secretion observed in healthy adults (Du

• Based on the previous report that FXR

  2021-11-12

  

  Based on the previous report that FXR regulated PEPCK indirectly [20], we speculated that FXR may regulate gluconeogenesis by regulating some key transcription factors associated with gluconeogenesis. Finally, by using HS218 as a probe, we found that FXR binds to PGC-1α promoter and directly regulat

• Fibroblast growth factor receptors FGFRs play an essential r

  2021-11-12

  

  Fibroblast growth factor receptors (FGFRs) play an essential role in the regulation of cell survival, proliferation, migration and differentiation. FGFRs are a family of receptor tyrosine kinases (RTKs) exhibiting an extracellular immunoglobulin (Ig)-like ligand binding domain, a transmembrane domai

• We have presented evidence that only muscle FBPase

  2021-11-12

  

  We have presented evidence that only muscle FBPase is detectable within HL-1 cells. This is consistent with past findings of the Eschrich's group, which showed that in rat heart fatty acid amide hydrolase expression of FBPase is almost exclusively limited to the muscle isozyme [3]. Results of our p

• The presence of FBP in nuclei seems to accompany

  2021-11-12

  

  The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas

• Our previous work demonstrated that KDM regulates cellular o

  2021-11-12

  

  Our previous work demonstrated that KDM5 regulates cellular oxidative stress in Drosophila (Liu et al., 2014, Liu and Secombe, 2015). It is known that gut epithelial kh7 contacted by enteric commensal bacteria generate reactive oxygen species in response to microbial signals (Jones and Neish, 2017)

• br Hippo Signaling in Autoimmunity An imbalance

  2021-11-12

  

  Hippo Signaling in Autoimmunity An imbalance of T cell subsets, such as immunosuppressive regulatory T Ro 5-3335 (Treg) and inflammatory TH17, has a key role in autoimmune diseases. Recently, investigations found that TAZ but not YAP enhances TH17 differentiation but attenuates Treg differentiati

• r407 It has been well established that triazophos is a

  2021-11-12

  

  It has been well established that triazophos is a classic resurgence-inducing insecticide favoring N. lugens population growth by fecundity stimulation, with enhanced contents of soluble sugar, crude fat, soluble protein content of fat body and ovary, glucose and trehalase activity but reduced treha

• The obtained sequence was deposited in GenBank under accessi

  2021-11-12

  

  The obtained sequence was deposited in GenBank under accession number MG703576; it showed a 99% identify with sample HE817764, reported as Demodex cornei, and with JF784000, reported as D. canis. Molecular and phylogenetic analyses and the morphological characteristics helped to rule out D. cornei.

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