• In addition to the regulation afforded

  2022-10-11

  

  In addition to the regulation afforded by calcineurin/NFAT axis, it has been shown that deregulation of some microRNAs (e.g. miR-155) can induce activation of Fas/FasL-in various cell types [72]. Furthermore, Fas–FasL interactions appear to be an important mechanism for the maintenance of immune pri

• The PI K AKT pathway is

  2022-10-11

  

  The PI3K/AKT pathway is known to affect cell cycle, survival, and apoptosis (Yu et al., 2006; Park et al., 2008). After phosphorylation by AKT, the cytoplasmic apoptotic protein bad (bcl-xl/bcl-2) cannot be transferred to the mitochondria and dissociates from the inhibition protein bcl-2 and bcl-xl,

• br Conflict of interest br Introduction Colorectal cancer CR

  2022-10-11

  

  Conflict of interest Introduction Colorectal cancer (CRC), characterized by high prevalence in elderly people, is one of the most common cancers of digestive tract. CRC severely affects human health and causes enormous social and economic burdens [[1], [2], [3]]. Although public health awarene

• Over the years a number of studies have reported

  2022-10-10

  

  Over the years, a number of studies have reported results concerning the behavior of the two endothelin receptor subtypes, ETA and ETB, that do not fit the classical model of two G protein-coupled receptors acting independently of one another. For example, in the rat anterior pituitary gland, both E

• Preadipocytes are capable of differentiating into lipid lade

  2022-10-10

  

  Preadipocytes are capable of differentiating into lipid-laden mature adipocytes. Lipid droplets are a prominent morphological feature of mature adipocytes, which is accumulated and maintained during adipocytes differentiation [26]. In this study, rHhip treatment increased lipid accumulation, as well

• Aspartame l aspartyl l phenylalanine methylester

  2022-10-10

  

  Aspartame (l-aspartyl l-phenylalanine methylester) is a dipeptide artificial sweetener that is widely used as a non-nutritive sweetener in various food products [1]. The increased market of dietary products and the development of new synthetic sweetening compounds have not been sufficiently explored

• Main Text There are over small GTPases that

  2022-10-10

  

  Main Text There are over 200 small GTPases that play critical roles in diverse fundamental cellular processes such as signal transduction, calcium atpase dynamics, and intracellular trafficking. Most of the GTPases act as switch-like molecules by cycling between the guanosine triphosphate (GTP)-bo

• While published data around the functional

  2022-10-10

  

  While published data around the functional significance of GPR84 are quite sparse, details of signaling pathways initiated by the receptor are even more limited, including in recombinant systems. In recombinant cells, GPR84 activation reportedly leads to Gi pathway activation, resulting in pertussis

• GPR belongs to the G protein coupled

  2022-10-10

  

  GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty sesamin (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone marrow, s

• br Material and methods br Results

  2022-10-10

  

  Material and methods Results The search for proteins selectively expressed in pancreatic islet renin inhibitor in the Human Protein Atlas (HPA) yielded 27 hits, including well-known islet cell markers such as insulin, glucagon and pancreatic polypeptide (Table 1). The search algorithm exclude

• In the brain hydrolysis of AG by MGL

  2022-10-10

  

  In the brain, hydrolysis of 2-AG by MGL is the primary source of AA for conversion to PGs by cyclooxygenase (Nomura et al., 2011). PGE2 production is required for IL-1β-evoked synapse loss (Mishra et al., 2012). Here, we tested whether decreased PG levels contributed to the synapse protective effect

• Polyunsaturated fatty acids PUFAs represent a class of

  2022-10-10

  

  Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic osi sc 175 (DHA), eicosapentaenoic acid (EPA) and n-6 such as arachidonic acid (

• br Results br Discussion ER

  2022-10-09

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• The effects of FFAR and FFAR activation in different tissues

  2022-10-08

  

  The effects of FFAR1 and FFAR2 activation in different tissues have been reported in several species (Hara et al., 2014). Herein, we report the first evidence for differential expression of FFAR1 and FFAR2 during the peripartal period in the liver of dairy cows that differ in liver metabolism, based

• 5402 synthesis The subcellular redistribution of some metabo

  2022-10-08

  

  The subcellular redistribution of some metabolic enzymes is dynamic and responsive to metabolic conditions. In the absence of glucose, Glucokinase (GK) is bound to its regulatory protein in the nucleus of the hepatocyte and translocates to the cytoplasm when sugar levels increase [12]. Muscle glycog

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