• Pompe disease is accompanied by

  2022-11-17

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the kainate receptor unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in

• br Discussion Hepatic dysfunction in the metabolic syndrome

  2022-11-17

  

  Discussion Hepatic dysfunction in the metabolic syndrome is a driver of negative patient outcomes that requires more therapeutic options. The complexity of liver alterations in this disease – elevated de novo synthesis of fatty acids and cholesterol, reduced clearance of circulating atherogenic L

• br The lipoxygenase pathway and microvascular complications

  2022-11-17

  

  The 12/15-lipoxygenase pathway and microvascular complications of diabetes The 12/15-lipoxygenase pathway in adipose tissue Only recently has adipose tissue been recognized as a highly metabolically active endocrine organ imparting profound local and systemic inflammatory effects. Adipose tiss

• br There are three types of HT receptors

  2022-11-17

  

  There are three types of 5-HT2 receptors. 5-HT2A, 5-HT2B and 5-HT2C receptors Exhibit 46–50% overall sequence identity and couple preferentially to Gq/11 to increase inositol phosphates and cytosolic [Ca2+] and in agreement with their long known role in muscle contraction and stimulation in the br

• Interestingly as observed with Treg

  2022-11-17

  

  Interestingly, as observed with Treg cells, adenosine can regulate the function of Breg cells, a subset of immunosuppressive cells that support immunological tolerance [115]. In particular, Bregs were able to regulate both their own function and T cell activity via an adenosine signaling originating

• Additional evidence for a putative role of COXs and

  2022-11-16

  

  Additional evidence for a putative role of COXs and 5-LOX in AD derives from pharmacological studies using inhibitors of these enzymes (for review, see Firuzi and Praticò, 2006). In addition to helping delineate the pathobiological mechanisms of AD, these results raise hope for discovering novel the

• NOXA a member of the pro apoptotic B cell

  2022-11-15

  

  NOXA, a member of the pro-apoptotic B-cell lymphoma 2 (BCL-2) family, plays a vital role in regulating mitochondrial or inherent apoptotic pathways [7,8]. NOXA binds to MCL-1 with high affinity and interacts with A1 (known as BCL2A1), resulting in BIM release to trigger subsequent apoptosis [9]. In

• br Removal of therapeutic doses of antibiotics

  2022-11-14

  

  Removal of therapeutic doses of PF 04418948 mg from Marek’s Disease Vaccines The impact of this change seems to vary widely among operations, probably dependent on the pre-existing quality of hatching egg production, hatchery sanitation, hatchery management, and brooding management. Increases in

• br Conflicts of interest br Introduction When

  2022-11-14

  

  Conflicts of interest Introduction When it comes to risk taking, surgeons and anesthesiologists show greater risk taking than other physicians. Surgical procedures carry several risks of which infection is one. Surgical site infections (SSI) are the most common hospital acquired infection and

• Introduction Cardiovascular disease is the principal cause o

  2022-11-14

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with 6656 synthesis (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascul

• In the current investigation we studied the effect of propof

  2022-11-14

  

  In the current investigation, we studied the effect of propofol on prostate cancer cells. Propofol is one of the most commonly used drugs in the critical care setting and for the induction of general anesthesia and moderate and deep sedation intraoperatively. Recent studies indicated that propofol e

• Introduction Induction of long term potentiation LTP the

  2022-11-11

  

  Introduction Induction of long-term potentiation (LTP), the cellular correlate of learning and memory, triggers profound changes in the structure and function of excitatory synapses by increasing dendritic spine size and synaptic strength. Significant progress has been made in understanding the int

• As noted earlier the PfkB family of carbohydrate

  2022-11-09

  

  As noted earlier, the PfkB family of carbohydrate kinases can phosphorylate the hydroxymethyl group of a wide variety of sugar moieties [1], [3]. Recent searches of the Swiss-Prot database with the two conserved sequence motifs found in these proteins (Accession nos. PS00583 and PS00584) identified

• Sperm total motility and hyperactivated motility are mediate

  2022-11-09

  

  Sperm total motility and hyperactivated motility are mediated by PLD-dependent IFN-alpha 1, human recombinant protein polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm demonstrati

• Introduction Mammalian cells express the seven STAT family

  2022-11-09

  

  Introduction Mammalian Resiquimod express the seven STAT family members STAT1, −2, −3, −4, −5A, −5B, and −6 [1], [2]. All STATs exert physiologically important roles as homo- and heterodimers [2], [3], [4]. Cytokines and growth factors activate STATs through the activation of kinases that phosphor

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